| SHI Dayong,XU Feng,HE Juan,SHI Jiangong,FAN Xiao,HAN Lijun. 2008. Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell. Acta Oceanologica Sinica, (1):147－151 |
| Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell |
| Crystallographic and NMR studies on sterols from green alga Chaetomorpha basiretorsa Setchell |
| Received:November 17, 2006 Revised:June 20, 2007 |
| DOI： |
| Key words:green alga sterol X-ray crystal structure |
| 中文关键词: green alga sterol X-ray crystal structure |
| 基金项目:The State "863" High Tech Programof China under contract Nos 2007 AA09Z410 and 2007 AA091604;Key Innovative Project of the Chinese Academy of Sciences under contract No.KZCX2-YW-209. |
| Author Name | Affiliation | E-mail | | SHI Dayong | Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China | | | XU Feng | Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China | | | HE Juan | Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China | | | SHI Jiangong | Institute of Materia Medica, Chinese Academy of Medical Sciences and Beijing Union Medical College, Beijing 100050, China | | | FAN Xiao | Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China | | | HAN Lijun | Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China | ljhan@ms1qdio.ac.cn |
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| Abstract: |
| Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4, 28-dien-3α, 6β-diol 1 in addition to the five known sterols of β-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl-cholesterol 4, β-stigmasterol 5, 29-hydroxystigmasta-5, 24(28)-dien-3β-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH-20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard MTT method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive (50% inhibitory concentration was greater than 10 μg/cm3) against KB, Bel-7402, PC-3M, Ketr 3 and MCF-7 cell lines. |
| 中文摘要: |
| Chemical investigation of the ethanol extract of the marine green alga Chaetomorpha basiretorsa Setchell led to the isolation of a new sterol stigmast-4, 28-dien-3α, 6β-diol 1 in addition to the five known sterols of β-lawsaritol 2, saringosterol 3, 24-hydroperoxy-24-vinyl-cholesterol 4, β-stigmasterol 5, 29-hydroxystigmasta-5, 24(28)-dien-3β-ol 6. Compounds were isolated by normal phase silica gel and Sephadex LH-20 gel colum chromatography, reverse phase HPLC and recrystalization. Their structures were elucidated by spectroscopic methods including MS, IR 1D/2D NMR and X-ray analysis. Cytotoxicity of compounds was screened by using the standard MTT method. All these compounds were isolated from the green alga Chaetomorpha basiretorsa Setchell for the first time and they were inactive (50% inhibitory concentration was greater than 10 μg/cm3) against KB, Bel-7402, PC-3M, Ketr 3 and MCF-7 cell lines. |
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