| HUANG Zhouying,CHEN Yixin,WANG Chonggang,ZHAO Yang,ZUO Zhenghong. 2007. Effects of tributyltin at environmental levels on monooxygenase system of digestive gland in hard clam Meretrix meretrix. Acta Oceanologica Sinica, (2):144－149 |
| Effects of tributyltin at environmental levels on monooxygenase system of digestive gland in hard clam Meretrix meretrix |
| Effects of tributyltin at environmental levels on monooxygenase system of digestive gland in hard clam Meretrix meretrix |
| Received:March 25, 2006 Revised:December 14, 2006 |
| DOI： |
| Key words:tributyltin (TBT) monooxygenase system activity Meretrix meretrix |
| 中文关键词: tributyltin (TBT) monooxygenase system activity Meretrix meretrix |
| 基金项目: |
| Author Name | Affiliation | E-mail | | HUANG Zhouying | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciencse, Xiamen University, Xiamen 361005, China
Department of Biology, Quanzhou Normal University, Quanzhou 362000, China | | | CHEN Yixin | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciencse, Xiamen University, Xiamen 361005, China | | | WANG Chonggang | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciencse, Xiamen University, Xiamen 361005, China | | | ZHAO Yang | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciencse, Xiamen University, Xiamen 361005, China | | | ZUO Zhenghong | Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, School of Life Sciencse, Xiamen University, Xiamen 361005, China | zuozhenghong@xmu.edu.cn |
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| Abstract: |
| The effects on ethoxyresorufin O-deethylase (EROD), NADPH-cytochrome c reductase and NADH cytochrome b5 reductase activities of digestive gland in Meretrix meretrix exposed to tributyltin (TBT) at environmental levels (0.1, 1.0, 10.0 ng/dm3 as stannum concentration), in experimental condition, were evaluated.The EROD, NADH cytochrome b5 reductase activities were significantly inhibited after exposure to 10.0 ng/dm3 TBT for 8 and 20 d, the NADPH cytochrome c reductase activities were significantly inhibited after exposure to 0.1, 1.0 and 10.0 ng/dm3 TBT for 8 d and to 1.0 and 10.0 ng/dm3 for 20 d, as compared with the matched control, while NADH cytochrome b5 reductases and NADPH cytochrome c reductase activities were induced after exposure to 10.0 ng/dm3 TBT for 2 d.The EROD activity in the 10 ng/dm3 group, and the NADH cytochrome b5 reductases activities in 1.0 and 10.0 ng/dm3 groups, were significantly induced when transferred to clean recovery tanks for 7 d.The three enzymic activities in the clams exposed to TBT were recovered to the level corresponding to that of the control group after transfer to clean recovery tanks for 20 d.NADPH cytochrome c reductase activity in Meretrix meretrix seems to be more sensitive to exposure of TBT than that of the EROD and NADH cytochrome b5 reductases.The results suggest that induction and inhibition by TBT to the monooxygenase system enzymic activity in Meretrix meretrix would simultaneously exist.The enzymic activities were inhibited by exposure for a long time.The results suggest that inhibition of the monooxygenase system should be an indication of the exposure to environmentally relevant concentrations of TBT for a long time. |
| 中文摘要: |
| The effects on ethoxyresorufin O-deethylase (EROD), NADPH-cytochrome c reductase and NADH cytochrome b5 reductase activities of digestive gland in Meretrix meretrix exposed to tributyltin (TBT) at environmental levels (0.1, 1.0, 10.0 ng/dm3 as stannum concentration), in experimental condition, were evaluated.The EROD, NADH cytochrome b5 reductase activities were significantly inhibited after exposure to 10.0 ng/dm3 TBT for 8 and 20 d, the NADPH cytochrome c reductase activities were significantly inhibited after exposure to 0.1, 1.0 and 10.0 ng/dm3 TBT for 8 d and to 1.0 and 10.0 ng/dm3 for 20 d, as compared with the matched control, while NADH cytochrome b5 reductases and NADPH cytochrome c reductase activities were induced after exposure to 10.0 ng/dm3 TBT for 2 d.The EROD activity in the 10 ng/dm3 group, and the NADH cytochrome b5 reductases activities in 1.0 and 10.0 ng/dm3 groups, were significantly induced when transferred to clean recovery tanks for 7 d.The three enzymic activities in the clams exposed to TBT were recovered to the level corresponding to that of the control group after transfer to clean recovery tanks for 20 d.NADPH cytochrome c reductase activity in Meretrix meretrix seems to be more sensitive to exposure of TBT than that of the EROD and NADH cytochrome b5 reductases.The results suggest that induction and inhibition by TBT to the monooxygenase system enzymic activity in Meretrix meretrix would simultaneously exist.The enzymic activities were inhibited by exposure for a long time.The results suggest that inhibition of the monooxygenase system should be an indication of the exposure to environmentally relevant concentrations of TBT for a long time. |
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